Wade, 37, nailed an incredible hail-mary shot on the buzzer to see the Heat stun NBA champions the Golden State Warriors 126-125 on Wednesday.
The Heat were trailing by two points with less than a second remaining but Wade stepped up and nailed a dramatic three-pointer, sparking wild scenes in Miami.
Wade, who is retiring at the end of the season, finished with 25 points and seven rebounds off the bench.
Miami are now 27-33 for the season and a half game out of the final playoff spot in the Eastern Conference, while the Warriors fell to 43-18 in the west.
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